Fehr's screen appearances include the 2001-02 NBC series UC: Undercover, the 2002-03 CBS series Presidio Med, and the 2004 movie release Resident Evil: Apocalypse (he reprised the role in the sequel, Resident Evil: Extinction). He also provided the voice of Doctor Fate in Justice League Unlimited. He also played Antoine Laconte, a male prostitute in Rob Schneider's comedy Deuce Bigalow: Male Gigolo (1999) and made a cameo appearance as Antoine Laconte in Deuce Bigalow: European Gigolo (2005). He also acted in the American hit supernatural series Charmed, where he played the evil demon Zankou, nearly killing the Charmed Ones. Director Stephen Sommers was one of the people who helped in giving Oded his big break in the film The Mummy and The Mummy Returns.

Between 2005-2006 Fehr played Farik on the Showtime series Sleeper Cell. In 2010, Fehr guested in the fourth episode of USA's Covert Affairs as an Israeli Mossad operative.

Fehr was born in Tel Aviv, Israel to Jewish parents, his mother a day care supervisor and his father a German-born physicist. He has an older brother, a sister, and a younger half-sister. He trained at the Bristol Old Vic Theatre School in England after taking a very brief drama class in Frankfurt, Germany. He served in the Israeli Sea Corps from 1989 to 1992 and used to work for security for El Al (Israel's airline) in Germany.

Fehr is married to Rhonda Tollefson, whom he met at a Los Angeles opera. They married on December 22, 2000. The couple have two children: son Atticus (born January 4, 2003) and daughter Finley (born February 26, 2006). Fehr speaks Hebrew, Arabic, English and some German.